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Search & Buy Flights from the US to South America

Book USA to South America Flights

Are you looking for flights from the USA to South America? Take a look at our handy guide below to help you explore which airlines operate frequent popular routes between the USA and countries within South America, which departure and arrival airports to consider flying into and many more FAQs.


Popular USA to South America

Orlando ➡ San Jose

A popular route between the USA and South America is from Orlando to San Jose. San Jose is the capital and largest city of Costa Rica. San Jose is known for its natural beauty, incredible national parks and vibrant nightlife. If you're an animal lover then San Jose is the perfect destination for you. You can discover interesting wildlife including macaws, sea turtles and cute sloths. Airlines that schedule flights from Orlando to San Jose include SpiritCopa AirlinesAviancaAeromexicoJetblue United Airlines, and American Airlines.

Route Frequency: 
80+ weekly flights from Florida to San Jose

Ticket Price:
 $200+ USD single, $400+ USD return

Flight Time: 3-4 hours (direct)

Orlando International Airport ➡ Juan Santamaría International Airport

Spirit Airlines, Copa Airlines, Avianca, Aeromexico, American Airlines, United Airlines and many more!

Miami ➡ Bogotá

Are you looking to travel from Miami to Bogotá? Well, you'll be happy to hear that it's really easy to fly to Bogotá, especially if you're flying from Miami. When you arrive in Bogotá, you must taste the delicious Latin treats including milhoja, torta de tres leches, roscones and more. Bogota offers one of the best nightlife in Latin America. There are a number of world-class dinings and bars that you need to try out when visiting. Airlines that fly out frequently from Miami to Bogotá include JetBlue, American Airlines, Avianca, LATAM and Spirit Airlines.

Route Frequency: 
60+ weekly flights from Miami to Bogotá

Ticket Price:
 $250+ USD single, $350+ USD return

Flight Time: 
3-4 hours (direct)

Miami International Airport ➡ El Dorado International Airport

 JetBlue, American Airlines, Avianca, LATAM and Spirit Airlines.

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Buy Now, Pay Later For USA to South America Flights

Did you know that you can buy flights from the US to South America today and spread the cost over time? Here, at Alternative Airlines we offer over 40 different ways to pay including many buy now, pay later options. This includes Afterpay, Klarna, Tendopay and many more!

If you currently live in the United States, you can buy flights from the USA to South America and break up the costs in easy-to-pay instalments with KlarnaAfterpayAffirmZip, and PayPal Credit. Depending on the payment plan provider you select at checkout, you can split the cost of your flight over a weekly, bi-weekly or even monthly basis. Please note that the payment plan options available will depend on the country you live in. Find out more by reading our Buy Now, Pay Later guide.

What Airlines Fly Between the USA and South America?

Direct Flights: If you're aiming to travel direct from the US to South America without making any connections or layovers, the following airlines can provide. These airlines operate direct flights between the USA and a number of on a regular basis.

American Airlines

American Airlines is a major airline based in the United States and headquartered in Fort Worth, Texas. The airline is known as the world's largest airline when measured by the size of its fleet and the number of scheduled passengers carried. American Airlines operates flights to over 350 destinations internationally and domestically, including many cities in Brazil, Colombia, Chile, Costa Rica, Cuba, Ecuador and more.

United Airlines

United Airlines, also referred to as United, is another major airline based in the US. The airline is headquartered in Chicago, Illinois and flies to over 300 destinations globally, including many cities across South America. United is a fantastic airline option if you're looking to fly from the USA to South America.


LATAM Airlines is a South American airline, headquartered in Santiago, Sao Paulo, Brazil and Chile. The airline flies to over 135 destinations including Chile, Argentina, Perú, Brazil and Colombia. LATAM Airlines is a great airline if you're looking to fly from the USA to South America.

Copa Airlines

Copa Airlines is the flag carrier of Panama headquartered in Panama City. Copa Airlines operates many flights from its hub airport in Tocumen International Airport. The airline flies to over 80 destinations including Rio de Janeiro, San Jose, Punta Cana, Willemstad and more.


Avianca is the flag carrier of Colombia serving the region of Bogotá. The airline has a hub in El Dorado International Airport with many other secondary hubs in Medellin, Cali, and Cartagena. If you're looking to fly from the United States to South America, Avianca is a great option as it flies to many Latin destinations including Cancun, Guatemala, Mexico City, Panama, and Punta Cana.

Use the search form at the top of the page to begin searching for flights with any of these airlines and more.

You can also use our airline filters to only view flights with a specific airline, direct flights and different flight times.

Airport Information

Departure Airport Information

When flying from the USA to South America, the easiest airports to fly from are New York-JFK, Los Angeles International Airport and Miami International Airport.

John F. Kennedy International Airport (JFK)

John F. Kennedy International Airport also referred to as JFK, is the main international airport serving the region of the New York metropolitan area. It's known as the 13th busiest airport in the United States. This airport serves as a hub for American Airlines and Delta Air Lines. JFK is a common airport if you're looking to fly out to South America. From this airport, you can fly and visit Bogota, Cancún, San Jose, Panama City and many more.

Los Angeles International Airport (LAX)

Los Angeles International Airport (LAX), is the primary international airport serving Los Angeles and surrounding areas. This airport serves as a hub for Alaska Airlines, America Airlines, Delta Air Lines, and United Airlines. If you're flying from Los Angeles Airport, you can fly to the following South American cities: San Jose, Panama, Santiago de Chile, Lima and more.

Miami International Airport (MIA)

Miami International Airport (MIA), also known as MIA is the primary airport serving the greater Miami metropolitan area. The airport operates over 1,000 flights on a daily basis to over 160 destinations domestically and internationally. MIA is a hub for a number of airlines including American Airlines, Atlas Air, iAero Airways, Mas Air and more. If you are travelling from the US to a city in South America, then MIA is a great airport to depart from. Some of the busiest routes from Miami international airport include São Paulo, Havana, Panama City, Bogota, Mexico and Santo Domingo.

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Can I fly directly between the USA and South America?

Of course! There are a number of airports in the United States that you can depart from if you wish to travel to South America. There are also several airlines that fly direct routes to South American cities including American Airlines, Spirit, Avianca, LATAM, Copa Airlines, Aeromexico and many more. With these airlines, you can fly to some of the most popular South American destinations including Machu Picchu, Buenos Aires, Rio de Janeiro, Sao Paulo, Cartagena and more.

What is the flight time between the US and South America?

This changes depending on where in South America you plan to fly to and also where you're departing from. If you're flying from Miami to Bogota then the flight journey may last between 3-4 hours (direct). However, if you're flying from Orlando to Rio de Janeiro the flight journey will take approx, 7-8 hours (direct).

Can I pay overtime for flights between the USA and South America?

Absolutely! When you book flights from the USA to South America through Alternative Airlines you can spread the cost of your flight tickets over time. Alternative Airlines offers a number of payment plan providers on the site including Afterpay, TendoPay, Klarna, Affirm and PayPal Credit. That means that you can book any flight from the USA to South America and pay over weekly bi-weekly or monthly instalments. Discover all of our finance options here for more information.