Airline flying between the UK & US
American Airlines is one of the top 3 carriers in the United States and a member of the oneworld alliance with destinations across the country. You can fly directly between the US and the UK and catch any flights to other domestic destinations within the network or through its codeshare/interline partners.
British Airways is the flag carrier of Britain and a member of the oneworld alliance that is based at London Heathrow and offers direct US services from London Heathrow and Manchester Airport to multiple US destinations. The airline has a codeshare agreement with American Airlines, which means you can then fly domestically to the airports they offer.
Delta Airlines is one of the biggest carriers in the United States and a founding member of the SkyTeam alliance. It's serving around 200 million passengers per year with services between the UK and the US and codeshare agreements with airlines like Air France-KLM, and Virgin Atlantic.
JetBlue Airways is a low-cost airline in the United States with only a couple of routes between the two countries launched earlier in 2021. Flights are available from Boston to London Heathrow Airport and London Gatwick Airport.
United Airlines is a major airline in the USA and a founding member of the Star Alliance. The airline is based at Chicago O'Hare Airport and offers services to London Heathrow and Edinburgh Airport. It has a subsidiary airline named United Express, operating many domestic routes for the airline.
Virgin Atlantic is a British airline located at London Gatwick Airport but operates out of London Heathrow Airport and Manchester Airport to and from the US. As it has a codeshare/interline agreement with Delta Airlines, you'll be able to fly to and from smaller domestic destinations within the US.